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Assistant Scientist DSP

Vacaturenummer: A2100098
Janssen Vaccines & Prevention - Leiden (Nederland)

For our client, Janssen Vaccines & Prevention, we are looking for an Assistant Scientist DSP.


  • BSc. or MSc.
  • Downstream Processing
  • Protein Purification
  • Protein Analysis
  • High Troughput

The Bacterial Vaccines department is looking for an Assistant Scientist to join the Downstream Process Development (DSP) team. You will be part of a dynamic team driving research-scale production and characterization of bacterial vaccine candidates, mainly consisting of protein- and glycoprotein antigens. To this end, the DSP team develops and characterizes a broad range of biopharmaceutical DSP units using, amongst others, high-throughput process development methodologies and develops end-to-end purification processes at different scales. These newly developed purification processes are used for producing research-grade material for preclinical evaluation and are transferred to early process development partners.
As an Assistant Scientist DSP, you will support the Downstream Process Development team in performing purification experiments and in-process monitoring assays to facilitate early-stage bacterial vaccine development.
Your main responsibilities will be:
  • Supporting and executing purification and filtration experiments;
  • Preparation and execution of (high throughput) in-process monitoring assays;
  • Transferring in-process monitoring assays (plate based) to high-throughput platforms;
  • Performing (preliminary) data analysis, reporting and presentation of the main conclusions to the DSP team;
  • Experimental documentation in an electronic laboratory notebook (ELN);
  • Preparation of process documentation, including work instructions and batch records;
  • Handling laboratory stocks and keeping inventories up to date;
  • Keeping track of equipment status and/or maintenance;
  • Keeping systems in place for inventory/tracking of samples and process intermediates;
  • Following safety procedures, contribute to the maintenance of clean laboratory environment.

Who we're looking for
The ideal candidate has a BSc. or MSc. background in Biochemistry, Biotechnology, Biological engineering or related fields. You have at least one year relevant experience (internship also counts as experience) with protein or glycoprotein purification methods. You have a good understanding of analytical techniques to analyze proteins (e.g. plate-based colorimetric assays, capillary electrophoresis, ELISA, Western blotting, BLI, SDS-PAGE, UPLC-based techniques) and knowledge of high-throughput platforms and liquid handling systems.
Are you a teamplayer with excellent communication skills? Are you organized and methodic in data generation and handling? Then we are looking for you!

Company profile
Janssen Vaccines & Prevention B.V. is part of Johnson & Johnson, one of the biggest and most respected health care companies in the world. They are dedicated to bringing meaningful innovation to global health. Their teams focus on the discovery, development, manufacturing, and marketing of novel vaccines to prevent some of the most devastating and complex infectious diseases. These range from respiratory infections like respiratory syncytial virus (RSV) to human immunodeficiency virus (HIV) and pathogens of global concern, such as Ebola and COVID-19.
In this organization, entrepreneurial people are working in a dynamic culture in which innovation and a 'can do' state of mind are of crucial importance. They are continuously looking for enthusiastic, talented people who have the ambition to develop themselves and can be of value to Janssen. The offices of Janssen Vaccines & Prevention are located in Leiden, The Netherlands.

The Bacterial Vaccines department is working on the discovery- and early development of novel vaccines for bacterial infectious diseases. We strive to address unmet medical needs, such as bacteria (sepsis) and nosocomial infections. Projects at the Bacterial Vaccines department are primarily structured on scientific- and technical collaboration with external biotechnology partners (governmental and industrial) that are innovative leaders in their field. This working process includes ‘state of the art’ vaccine discovery, with subsequent in vivo evaluation of these vaccine candidates in animal models for immunogenicity and/or efficacy. In addition, manufacturing processes are optimized and established, and the resulting clinical trial material is evaluated in human clinical studies.

Additional vacancy information
Contract:Temporary contract with CLS Services
Education:WO/MSc. HBO/BSc.
Employment terms:Contract for at least one year, extension possible.
Salary: > 2600
Days of leave: 25 + 13
See here our other employment terms for this vacancy
Publication date:3-5-2021
Location:View location with Google Maps
Contactperson:Claudia Erwich-Faaij
+31 (0)88 22 77 555

CLS Services is a leading professional recruitment agency, specialised in the recruitment and career coaching of people with a background in chemistry & life sciences.